Paroxysmal nocturnal hemoglobinuria epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

The incidence of paroxysmal nocturnal hemoglobinuria is approximately 0.13 per 100,000 individuals worldwide. Paroxysmal nocturnal hemoglobinuria commonly affects adults. However, some cases of PNH in the childhood have been reported.

Epidemiology and Demographics

Incidence

The incidence of paroxysmal nocturnal hemoglobinuria is approximately 0.13 per 100,000 individuals worldwide.^[1]

Age

Paroxysmal nocturnal hemoglobinuria commonly affects adults. However, some cases of PNH in the childhood have been reported.^[2]

Race

There is no racial predilection to [disease name].

Gender

Paroxysmal nocturnal hemoglobinuria affects men and women equally.

References

↑ Borowitz MJ, Craig FE, Digiuseppe JA, Illingworth AJ, Rosse W, Sutherland DR; et al. (2010). “Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry”. Cytometry B Clin Cytom. 78 (4): 211–30. doi:10.1002/cyto.b.20525. PMID 20533382.
↑ Curran KJ, Kernan NA, Prockop SE, Scaradavou A, Small TN, Kobos R; et al. (2012). “Paroxysmal nocturnal hemoglobinuria in pediatric patients”. Pediatr Blood Cancer. 59 (3): 525–9. doi:10.1002/pbc.23410. PMID 22147651.

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[pmid20533382-1] Borowitz MJ, Craig FE, Digiuseppe JA, Illingworth AJ, Rosse W, Sutherland DR; et al. (2010). “Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry”. Cytometry B Clin Cytom. 78 (4): 211–30. doi:10.1002/cyto.b.20525. PMID 20533382.

[pmid22147651-2] Curran KJ, Kernan NA, Prockop SE, Scaradavou A, Small TN, Kobos R; et al. (2012). “Paroxysmal nocturnal hemoglobinuria in pediatric patients”. Pediatr Blood Cancer. 59 (3): 525–9. doi:10.1002/pbc.23410. PMID 22147651.

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[2]