Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Paroxysmal nocturnal hemoglobinuria history and symptoms
Introduction
Overview
Overview
Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, dyspnea, headaches, abdominal pain, dysphagia and chest pain. Less common symptoms may include necrotic skin lesions.
History and Symptoms
History and Symptoms
History
Patients with PNH may have a positive history of:
- Feeling tired/ weak
- Shortness of breath
- Dark colored urine
- Jaundice
- Blood clots
- Difficulty swallowing
- Chest pain
- Abdominal pain
- Headaches
- Confusion
- Dysphagia
- Erectile dysfunction
- Low blood cell counts
- Iron deficiency
Common Symptoms
Common symptoms of PNH include:[1]
- Due to hemolysis
- Fatigue
- Dyspnea
- Jaundice
- Due to thrombosis:
- Headaches
- Confusion
- Abdominal pain
- Chest pain
- Due to nitric oxide depletion:
- Dysphagia
- Chest pain
- Abdominal pain
- Erectile dysfunction
Less Common Symptoms
Less common symptoms of PNH include:
References
References
- ↑ Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). “Diagnosis and management of paroxysmal nocturnal hemoglobinuria”. Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]