Health Dictionary
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Paroxysmal nocturnal hemoglobinuria natural history, complications and prognosis
Introduction
Overview
Overview
If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH. Common complications include intracranial thrombosis, splenic vein thrombosis, and portal vein thrombosis. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
Natural History, Complications, and Prognosis
Natural History, Complications, and Prognosis
Natural History
- If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH.
- PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly.
Complications
- Common complications of paroxysmal nocturnal hemoglobinuria include:
- Intracranial thrombosis
- Splenic vein thrombosis
- Portal vein thrombosis
Prognosis
- Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
- Eculizumab has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH.
References
References
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]