Paroxysmal nocturnal hemoglobinuria physical examination

Patients with paroxysmal nocturnal hemoglobinuria usually appear tired. Physical examination of patients with PNH is usually remarkable for fever, skin pallor, skin ecchymoses and skin nodules. Physical examination may show abdominal distension if PNH is associated with Budd-Chiari syndrome.

• Patients with paroxysmal nocturnal hemoglobinuria usually appear tired

• Fever may be present due to infections

• Pallor
• Skin ecchymoses
• Skin nodules if it is associated with dermal vein thrombosis

• Mucosal pallor

• Neck examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

• Pulmonary examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

• Cardiovascular examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

• Abdominal distention if associated with Budd-Chiari syndrome^[1]
• Hepatomegaly
• Splenomegaly

• Genitourinary examination of patients with paroxysmal nocturnal hemoglobinuria is usually normal

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