Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Pelger-Huet anomaly
Introduction
Overview
Pelger-Huet anomaly is a blood laminopathy associated with the lamin B receptor. It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.
It is a genetic disorder with an autosomal dominant inheritance pattern. Heterozygotes are clinical normal although their neutrophils may be mistaken for immature cells which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]