
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions โ written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Peripheral neuropathy history and symptoms
Introduction
Overview
Overview
Patients with peripheral neuropathy may have a positive history of: Metabolic disorder, long-standing illness, childhood clumsiness, unsteady gait and falls, Neurological diseases, neurological diseases, occupational inorganic lead exposure and Malignancy. The most common symptoms of peripheral neuropathy include: Gradual progressive numbness, Prickling or tingling in feet and hands, Burning pain in extremities, extreme sensitivity to touch, Ataxia, frequent falls, muscle weakness or paralysis, Constipation, diarrhea, early satiety, nausea, problems controlling bowel movements, Swallowing problems, Abdomen distention,Vomiting, impaired heart rate, resting tachycardia, exercise intolerance, abnormal blood pressure regulation, orthostatic hypotension, Heat intolerance and altered sweating, urine incontinence, pain (usually from optic neuritis), Vision loss, Visual field los, loss of color vision and flashing lights.
History and Symptoms
History and Symptoms
History
Patients with peripheral neuropathy may have a positive history of: Metabolic disorder, long-standing illness, childhood clumsiness, unsteady gait and falls, Neurological diseases, neurological diseases, occupational inorganic lead exposure and Malignancy.
Patients with peripheral neuropathy may have a positive history of:[1][2][3][4][5]
- Metabolic disorders
- Long-standing illness
- Childhood clumsiness
- Unsteady gait and falls
- Neurological diseases
- Neurological diseases
- Occupational inorganic lead exposure
- Malignancy
Common Symptoms
The most common symptoms of peripheral neuropathy include: Gradual progressive numbness, Prickling or tingling in feet and hands, Burning pain in extremities, extreme sensitivity to touch, Ataxia, frequent falls, muscle weakness or paralysis, Constipation, diarrhea, early satiety, nausea, problems controlling bowel movements, Swallowing problems, Abdomen distention,Vomiting, impaired heart rate, resting tachycardia, exercise intolerance, abnormal blood pressure regulation, orthostatic hypotension, Heat intolerance and altered sweating, urine incontinence, pain (usually from optic neuritis), Vision loss, Visual field los, loss of color vision and flashing lights.
The most common symptoms of peripheral neuropathy include:
- Gradual progressive numbness[6][7]
- Prickling or tingling in feet and [[[hands]][6][7]
- Burning pain in extremities[6]
- Extreme sensitivity to touch[6][7]
- Ataxia[8]
- Frequent falls[8]
- Muscle weakness or paralysis[6]
- Gastrointestinal symptoms:
- Constipation[9]
- Diarrhea[10]
- Early satiety[10]
- Nausea[11]
- Problems controlling bowel movements
- Swallowing problems[11]
- Abdomen distention[12]
- Vomiting[11]
- Cardiovascular symptoms:[13][14][15]
- Impaired heart rate
- Resting tachycardia
- Exercise intolerance
- Abnormal blood pressure regulation
- Orthostatic hypotension
- Heat intolerance and altered sweating[16]
- Urine incontinence:[17][18]
- Ocular symptoms:[19][20][21]
- Pain (usually from optic neuritis)
- Vision loss
- Visual field loss
- Loss of color vision
- Flashing lights
References
References
- โ Kelly JJ (2005). “Peripheral neuropathy: the importance of history and examination for correct diagnosis”. Rev Neurol Dis. 2 (3): 150โ3. PMIDย 16400316.
- โ Rubens O, Logina I, Kravale I, Eglรฎte M, Donaghy M (2001). “Peripheral neuropathy in chronic occupational inorganic lead exposure: a clinical and electrophysiological study”. J Neurol Neurosurg Psychiatry. 71 (2): 200โ4. PMCย 1737511. PMIDย 11459892.
- โ Keller MP, Chance PF (1999). “Inherited peripheral neuropathy”. Semin Neurol. 19 (4): 353โ62. doi:10.1055/s-2008-1040850. PMIDย 10716658.
- โ Sharma CM, Sears M (1990). “Metabolic neuropathy”. Clin Podiatr Med Surg. 7 (1): 97โ105. PMIDย 2405988.
- โ Storstein A, Vedeler C (2001). “Neuropathy and malignancy: a retrospective survey”. J Neurol. 248 (4): 322โ7. PMIDย 11374098.
- โ 6.0 6.1 6.2 6.3 6.4 Marchettini P, Lacerenza M, Mauri E, Marangoni C (2006). “Painful peripheral neuropathies”. Curr Neuropharmacol. 4 (3): 175โ81. PMCย 2430688. PMIDย 18615140.
- โ 7.0 7.1 7.2 Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H; et al. (2012). “The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA”. Support Care Cancer. 20 (3): 625โ32. doi:10.1007/s00520-011-1141-9. PMCย 3329939. PMIDย 21479990.
- โ 8.0 8.1 Linnemann C, Tezenas du Montcel S, Rakowicz M, Schmitz-Hรผbsch T, Szymanski S, Berciano J; et al. (2016). “Peripheral Neuropathy in Spinocerebellar Ataxia Type 1, 2, 3, and 6”. Cerebellum. 15 (2): 165โ73. doi:10.1007/s12311-015-0684-6. PMIDย 26054379.
- โ Yamada E, Namiki Y, Takano Y, Takamine H, Inazumi K, Sasaki H; et al. (2018). “Clinical factors associated with the symptoms of constipation in patients with diabetes mellitus: A multicenter study”. J Gastroenterol Hepatol. 33 (4): 863โ868. doi:10.1111/jgh.14022. PMIDย 29048762.
- โ 10.0 10.1 Pfluecke C, Ulbrich S, Ibrahim K, Geiger KD, Strasser RH, Wunderlich C (2013). “Chronic diarrhea as the initial clinical manifestation of light-chain amyloidosis with cardiac involvement despite negative duodenal and rectal biopsies”. Exp Clin Cardiol. 18 (2): 148โ50. PMCย 3718595. PMIDย 23940440.
- โ 11.0 11.1 11.2 Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G; et al. (2008). “The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology”. Brain. 131 (Pt 7): 1912โ25. doi:10.1093/brain/awn093. PMCย 2442424. PMIDย 18524793.
- โ Krishnan B, Babu S, Walker J, Walker AB, Pappachan JM (2013). “Gastrointestinal complications of diabetes mellitus”. World J Diabetes. 4 (3): 51โ63. doi:10.4239/wjd.v4.i3.51. PMCย 3680624. PMIDย 23772273.
- โ Pop-Busui R (2010). “Cardiac autonomic neuropathy in diabetes: a clinical perspective”. Diabetes Care. 33 (2): 434โ41. doi:10.2337/dc09-1294. PMCย 2809298. PMIDย 20103559.
- โ McCarty N, Silverman B (2016). “Cardiovascular autonomic neuropathy”. Proc (Bayl Univ Med Cent). 29 (2): 157โ9. PMCย 4790554. PMIDย 27034552.
- โ Bissinger A (2017). “Cardiac Autonomic Neuropathy: Why Should Cardiologists Care about That?”. J Diabetes Res. 2017: 5374176. doi:10.1155/2017/5374176. PMCย 5682059. PMIDย 29214181.
- โ Kenny GP, Sigal RJ, McGinn R (2016). “Body temperature regulation in diabetes”. Temperature (Austin). 3 (1): 119โ45. doi:10.1080/23328940.2015.1131506. PMCย 4861190. PMIDย 27227101.
- โ Burakgazi AZ, Alsowaity B, Burakgazi ZA, Unal D, Kelly JJ (2012). “Bladder dysfunction in peripheral neuropathies”. Muscle Nerve. 45 (1): 2โ8. doi:10.1002/mus.22178. PMIDย 22190298.
- โ Tanik N, Tanik S, Albayrak S, Zengin K, Inan LE, Caglayan EK; et al. (2016). “Association Between Overactive Bladder and Polyneuropathy in Diabetic Patients”. Int Neurourol J. 20 (3): 232โ239. doi:10.5213/inj.1632508.254. PMCย 5083825. PMIDย 27706007.
- โ DeMill DL, Hussain M, Pop-Busui R, Shtein RM (2016). “Ocular surface disease in patients with diabetic peripheral neuropathy”. Br J Ophthalmol. 100 (7): 924โ928. doi:10.1136/bjophthalmol-2015-307369. PMCย 5037046. PMIDย 26500330.
- โ Srinivasan S, Pritchard N, Sampson GP, Edwards K, Vagenas D, Russell AW; et al. (2017). “Diagnostic capability of retinal thickness measures in diabetic peripheral neuropathy”. J Optom. 10 (4): 215โ225. doi:10.1016/j.optom.2016.05.003. PMCย 5595257. PMIDย 27423690.
- โ Nightingale LM, Paviour DC (2009). “Nutritional optic and peripheral neuropathy: a case report”. Cases J. 2: 7762. doi:10.4076/1757-1626-2-7762. PMCย 2740016. PMIDย 19830009.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
