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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Peutz-Jeghers syndrome history and symptoms

Introduction

Overview

Overview

The hallmark of Peutz-Jeghers syndrome is hamatomatous polyps. A positive history of mucucutaneous hyperpigmentation and rectal bleeding is suggestive of Peutz-Jeghers syndrome. The most common symptoms of Peutz-Jeghers syndrome include abdominal pain, fatigue, and weight loss.

History and Symptoms

History and Symptoms

Individuals with Peutz-Jeghers syndrome may have positive history of:[1]

Symptoms of Peutz-Jeghers syndrome include the following:[1][2]_Genetic_and_Rare_Diseases_Information_Center_(GARD)_–_an_NCATS_Program-3|[3]

Percentage of symptom occurrence in Peutz-Jeghers syndrome
Symptoms Percentage (%)
Abnormal Pigmentation 80 to 90
GI Bleeding 30 to 79
Abdominal Pain 5 to 29
References

References

  1. ↑ 1.0 1.1 Kopacova, Marcela; Tacheci, Ilja; Rejchrt, Stanislav; Bures, Jan (2009). “Peutz-Jeghers syndrome: Diagnostic and therapeuticapproach”. World Journal of Gastroenterology. 15 (43): 5397. doi:10.3748/wjg.15.5397. ISSN 1007-9327.
  2. ↑ Giardiello, F; Trimbath, J (2006). “Peutz-Jeghers Syndrome and Management Recommendations”. Clinical Gastroenterology and Hepatology. 4 (4): 408–415. doi:10.1016/j.cgh.2005.11.005. ISSN 1542-3565.
  3. _Genetic_and_Rare_Diseases_Information_Center_(GARD)_–_an_NCATS_Program_3-0|↑ “Peutz-Jeghers syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program”.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]