Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Phosphamidon
Introduction
Overview
Overview
Phosphamidon is an organophosphate insecticide first reported in 1960. It acts as a cholinesterase inhibitor.
The commercial product typically exists as a mixture of 70% (Z)-isomer and 30% (E)-isomer.
Toxicity and regulation
Toxicity and regulation
Phosphamidon is very highly toxic to mammals and is listed as WHO Hazard Class Ia. A harvester developed symptoms of moderately severe poisoning after working in a field that had been sprayed with the chemical 2 weeks earlier. He collapsed and exhibited significant depression of serum cholinesterase, but recovered completely within 2 days after successful treatment with atropine.[4] International trade of phosphamidon is covered by the Rotterdam Convention.
References
References
- ↑ Data Sheet on Pesticides No. 74: Phosphamidon, International Programme on Chemical Safety
- ↑ 2.0 2.1 2.2 2.3 2.4 Jacques, R.; Bein, H. J. (1960). “Toxicology and pharmacology of a new systemic phosphoric acid ester insecticide phosphamidon (2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate)”. Archiv fuer Toxikologie. 18: 316–330.
- ↑ Bachmann, Fritz (1960). “Phosphamidon, a new phosphate ester with systemic action”. Proc. Intern. Cong. Crop. Protection, 4th Congr., Hamburg. 2: P1153–1155.
- ↑ S. Gitelson, J. T. Davidson, A. Werczberger. Phosphamidon poisoning. Brit. J. Ind. Med. 22: 236-239, 1965.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]