Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Piperaquine
Introduction
Overview
Overview
Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.[1]
Piperaquine is characterized by slow absorption and a long biological half-life,[2] making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.[3]
The fixed-dose combination dihydroartemisinin-piperaquine (Eurartesim) was submitted for approval to the European Medicines Agency in 2009.[4]
References
References
- ↑ Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF (2005). “Piperaquine: a resurgent antimalarial drug”. Drugs. 65 (1): 75–87. PMID 15610051.
- ↑ D’alessandro U. (2009). “Progress in the development of piperaquine combinations for the treatment of malaria”. Curr Opin Infect Dis. 22 (6): 588–92. PMID 19773652.
- ↑ http://apps.who.int/prequal/info_applicants/Guidelines/Nonclinical_Overview_Artemisinin-Derivatives.pdf“
- ↑ Medicines for Malaria. “Registration”. Retrieved 2010-06-20.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]