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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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PlGF

Introduction

Placental growth factor, vascular endothelial growth factor-related protein, also known as PGF, is a human gene.[1]

References

References

  1. ↑ “Entrez Gene: PGF placental growth factor, vascular endothelial growth factor-related protein”.
Further reading

Further reading

  • Luttun A, Tjwa M, Carmeliet P (2003). “Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders”. Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719.
  • Maglione D, Guerriero V, Viglietto G; et al. (1991). “Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor”. Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9267–71. PMID 1924389.
  • Maglione D, Guerriero V, Viglietto G; et al. (1993). “Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14”. Oncogene. 8 (4): 925–31. PMID 7681160.
  • Park JE, Chen HH, Winer J; et al. (1994). “Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR”. J. Biol. Chem. 269 (41): 25646–54. PMID 7929268.
  • Hauser S, Weich HA (1994). “A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta”. Growth Factors. 9 (4): 259–68. PMID 8148155.
  • Mattei MG, Borg JP, Rosnet O; et al. (1996). “Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively”. Genomics. 32 (1): 168–9. doi:10.1006/geno.1996.0098. PMID 8786112.
  • Ziche M, Maglione D, Ribatti D; et al. (1997). “Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic”. Lab. Invest. 76 (4): 517–31. PMID 9111514.
  • Vuorela P, Hatva E, Lymboussaki A; et al. (1997). “Expression of vascular endothelial growth factor and placenta growth factor in human placenta”. Biol. Reprod. 56 (2): 489–94. PMID 9116151.
  • Cao Y, Ji WR, Qi P; et al. (1997). “Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing”. Biochem. Biophys. Res. Commun. 235 (3): 493–8. doi:10.1006/bbrc.1997.6813. PMID 9207183.
  • Davis-Smyth T, Presta LG, Ferrara N (1998). “Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability”. J. Biol. Chem. 273 (6): 3216–22. PMID 9452434.
  • Landgren E, Schiller P, Cao Y, Claesson-Welsh L (1998). “Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1”. Oncogene. 16 (3): 359–67. doi:10.1038/sj.onc.1201545. PMID 9467961.
  • Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). “Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]”. J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
  • Renedo M, Arce I, Montgomery K; et al. (2000). “A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2”. Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.
  • Maglione D, Battisti M, Tucci M (2000). “Recombinant production of PIGF-1 and its activity in animal models”. Farmaco. 55 (3): 165–7. PMID 10919072.
  • Roberts-Clark DJ, Smith AJ (2000). “Angiogenic growth factors in human dentine matrix”. Arch. Oral Biol. 45 (11): 1013–6. PMID 11000388.
  • Iyer S, Leonidas DD, Swaminathan GJ; et al. (2001). “The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution”. J. Biol. Chem. 276 (15): 12153–61. doi:10.1074/jbc.M008055200. PMID 11069911.
  • Li XF, Charnock-Jones DS, Zhang E; et al. (2001). “Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells”. J. Clin. Endocrinol. Metab. 86 (4): 1823–34. PMID 11297624.
  • Su YN, Hsu JJ, Lee CN; et al. (2002). “Raised maternal serum placenta growth factor concentration during the second trimester is associated with Down syndrome”. Prenat. Diagn. 22 (1): 8–12. PMID 11810642.
  • Angelucci C, Lama G, Iacopino F; et al. (2002). “Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor”. Growth Factors. 19 (3): 193–206. PMID 11811792.
  • Mamluk R, Gechtman Z, Kutcher ME; et al. (2002). “Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain”. J. Biol. Chem. 277 (27): 24818–25. doi:10.1074/jbc.M200730200. PMID 11986311.

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