Platinosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Platinosis is an allergy-like reaction to exposure to soluble salts of platinum.
The symptoms of platinosis may include asthma, dermatitis, dyspnea, conjunctival vasodilatation, and rhinopharyngitis.
The symptoms are progressive, sometimes taking months to years to appear. Platinosis is usually associated with workers in industries related to platinum production. The effects are permanent.
Halogeno-platinum compounds are among the most potent respiratory and skin sensitisers known, therefore it is vital that exposure via the skin and by breathing contaminated air is carefully controlled.
In practice, the compounds mainly responsible for platinum sensitisation are typically the soluble, ionic, platinum-chloro compounds such as ammonium hexachloroplatinate and tetrachloroplatinate, and hexachloroplatinic acid. Other ionic halogeno compounds are also sensitisers, the order of allergenicity being Cl > Br > I.
Neutral compounds such as cis-platin and ammine and nitro complexes such as [Pt(NH3)4]Cl2, K2[Pt(NO2)4] and platinum nitrate are not considered to be allergenic; neither is the metal.
References
References
- Parrot, Jl; Hébert, R; Saindelle, A; Ruff, F (1969). “Platinum and platinosis. Allergy and histamine release due to some platinum salts”. Archives of environmental health. 19 (5): 685–91. PMID 4187030. Unknown parameter
|month=ignored (help) - Saindelle, A; Ruff, F; Hébert, R; Parrot, Jl (1968). “A new histamine liberator: chloroplatinate. An occupational allergy: platinosis”. Revue francaise d’allergologie (in French). 8 (4): 205–14. doi:10.1016/S0370-4688(68)80018-3. PMID 4180839. Unknown parameter
|trans_title=ignored (help); Unknown parameter|month=ignored (help) - Parrot, Jl; Saindelle, A; Ruff, F (1967). “Platinum and platinosis. Histamine release by some platinum salts and platinum allergy”. La Presse médicale (in French). 75 (55): 2817–20. PMID 4171373. Unknown parameter
|trans_title=ignored (help); Unknown parameter|month=ignored (help) - Parrot, Jl; Saindelle, A; Tazi, T (1963). “Histamine Liberation by Platinum Salts and the Mechanism of Platinosis”. Bulletin de l’Academie nationale de médecine (in French). 147: 458–62. PMID 14054203. Unknown parameter
|trans_title=ignored (help); Unknown parameter|month=ignored (help) - Roberts, Ae (1951). “Platinosis; a five-year study of the effects of soluble platinum salts on employees in a platinum laboratory and refinery”. A. M. A. Archives of industrial hygiene and occupational medicine. 4 (6): 549–59. PMID 14877314. Unknown parameter
|month=ignored (help)
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