Pleomorphic adenoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

Overview

There are no well established causes for pleomorphic adenoma. However some clonal chromosomal abnormalities with aberrations involving 8q12 and 12q15 have been described. Simian virus(SV40) is thought to play a role either in the onset or progression of the tumor.

Causes

There are no established causes for the development of pleomorphic adenoma.
However some clonal chromosomal abnormalities with aberrations involving 8q12 and 12q15 have been described.^[1]
Oncogenic simian virus(SV40) may play a role in the onset or progression of pleomorphic adenoma.^[2]

References

↑ Debnath SC, Adhyapok AK (June 2010). “Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip”. J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMID 22190789.
↑ Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M (October 2002). “Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands”. Am. J. Pathol. 161 (4): 1127–33. doi:10.1016/S0002-9440(10)64389-1. PMC 1867276. PMID 12368186.

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[pmid22190789-1] Debnath SC, Adhyapok AK (June 2010). “Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip”. J Maxillofac Oral Surg. 9 (2): 205–8. doi:10.1007/s12663-010-0052-5. PMID 22190789.

[pmid12368186-2] Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M (October 2002). “Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands”. Am. J. Pathol. 161 (4): 1127–33. doi:10.1016/S0002-9440(10)64389-1. PMC 1867276. PMID 12368186.

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Pleomorphic adenoma causes

Overview

Causes

References

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