Pleomorphic adenoma historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

Overview

Pleomorphic adenoma was first described by Minssen in 1874 in a monograph named Ahlbom’s. Later Mark and Dahlenfors in 1986 and Bullerdiek et al. in 1987 found some clonal chromosome abnormalities that are related to pleomorphic adenoma.

Historical Perspective

Discovery

In 1874, Minssen was the first to describe in detail about pleomorphic adenoma in monograph named Ahlbom’s.^[1]
Later in 1986, Mark and Dahlenfors found some clonal chromosome abnormalities related to pleomorphic adenoma, with a majority of them involving 8q12.^[2]
In 1987 Bullerdiek et al found another subset of tumors characterized by changes affecting 12q13-q15.^[3]

Landmark Events in the Development of Treatment Strategies

There is no much evidence on the landmark events in the development of treatment strategies.

Impact on Cultural History

There is no much evidence of pleomorphic adenoma on the impact on cultural history.

Famous Cases

There aren’t any famous cases on pleomorphic adenoma.

References

↑ Ghosh, Swapan Kr.; Saha, Jayanta; Chandra, Sudipta; Datta, Saumyajit (2011). “Pleomorphic Adenoma of the Base of the Tongue––A Case Report”. Indian Journal of Otolaryngology and Head & Neck Surgery. 63 (S1): 113–114. doi:10.1007/s12070-011-0136-7. ISSN 2231-3796.
↑ Bullerdiek J, Raabe G, Bartnitzke S, Böschen C, Schloot W (June 1987). “Structural rearrangements of chromosome Nr 8 involving 8q12–a primary event in pleomorphic ademona of the parotid gland”. Genetica. 72 (2): 85–92. PMID 3505884.
↑ Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W (1987). “Rearrangements of chromosome region 12q13—-q15 in pleomorphic adenomas of the human salivary gland (PSA)”. Cytogenet. Cell Genet. 45 (3–4): 187–90. doi:10.1159/000132452. PMID 3691185.

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[GhoshSaha2011-1] Ghosh, Swapan Kr.; Saha, Jayanta; Chandra, Sudipta; Datta, Saumyajit (2011). “Pleomorphic Adenoma of the Base of the Tongue––A Case Report”. Indian Journal of Otolaryngology and Head & Neck Surgery. 63 (S1): 113–114. doi:10.1007/s12070-011-0136-7. ISSN 2231-3796.

[pmid3505884-2] Bullerdiek J, Raabe G, Bartnitzke S, Böschen C, Schloot W (June 1987). “Structural rearrangements of chromosome Nr 8 involving 8q12–a primary event in pleomorphic ademona of the parotid gland”. Genetica. 72 (2): 85–92. PMID 3505884.

[pmid3691185-3] Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W (1987). “Rearrangements of chromosome region 12q13—-q15 in pleomorphic adenomas of the human salivary gland (PSA)”. Cytogenet. Cell Genet. 45 (3–4): 187–90. doi:10.1159/000132452. PMID 3691185.

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