Physical examination of patients with Plummer-Vinson syndrome is usually remarkable for glossitis, esophageal webs or strictures, and dysphagia. Other findings on physical examination include pallor, stomatitis, atrophy of lingual papillae, splenomegaly (33%), achlorhydria and koilonychia.

Physical examination of patients with Plummer-Vinson syndrome is usually remarkable for glossitis, esophageal webs or strictures, and dysphagia. Other findings on physical examination include:^{[1][2][3][4][5][6][7]}

• Patients with Plummer-Vinson syndrome usually appear fatigued

• Hypothermia may be present
• Tachycardia
• Normal to low blood pressure with normal pulse pressure

• Pale skin color (Pallor)
• Blue-tinged or very pale whites of eyes

• Stomatitis
• Glossitis
• Cheilitis
• Atrophy of lingual papillae
• Upper esophageal web or strictures on laryngoscopy

Odynophagia

• S1/S2 normal. Additional heart sound such as S3 may be heard in patients with high output heart failure

• Splenomegaly (33%)
• Achlorhydria

• Patient is usually oriented to time, place and person

• Koilonychia
• Brittle nails