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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Pneumoconiosis future or investigational therapies

Introduction

Overview

Overview

Future therapies for pneumoconiosis are being considered.

Future or Investigational Therapies

Future or Investigational Therapies

Future therapies are being experimented on including inhibiting cytokines and the use of antioxidants. Investigational therapy also includes administration of bone marrow-derived mononuclear cells. [1] [2] [3] In the case of berylliosis, the use of 5-aminosalicylic acid (ASA) is being considered as it improved the beryllium lymphocyte proliferation test (BeLPT) test by 20% after use for six weeks. [4] The use of tetrandrine, which is found in Chinese medical “han fang ji” has been experimented on and not proven effective. [5]

References

References

  1. ↑ Rimal B, Greenberg AK, Rom WN (2005). “Basic pathogenetic mechanisms in silicosis: current understanding”. Curr Opin Pulm Med. 11 (2): 169–73. doi:10.1097/01.mcp.0000152998.11335.24. PMID 15699791.
  2. ↑ Maron-Gutierrez T, Castiglione RC, Xisto DG, Oliveira MG, Cruz FF, Peçanha R; et al. (2011). “Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis”. Eur Respir J. 37 (5): 1217–25. doi:10.1183/09031936.00205009. PMID 20693250.
  3. ↑ Cavalli G, Fallanca F, Dinarello CA, Dagna L (2015). “Treating pulmonary silicosis by blocking interleukin 1”. Am J Respir Crit Care Med. 191 (5): 596–8. doi:10.1164/rccm.201412-2150LE. PMID 25723826.
  4. ↑ Day BJ, Huang J, Barkes BQ, Gillespie M, Li L, Maier LA (2018). “5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects”. Lung. 196 (1): 103–114. doi:10.1007/s00408-017-0062-x. PMID 29080069.
  5. ↑ Li QL (1981). “[The therapeutic effect of tetrandrine on silicosis (author’s transl)]”. Zhonghua Jie He He Hu Xi Xi Ji Bing Za Zhi. 4 (6): 321–3. PMID 7344866.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dushka Riaz, MD