Poikilocytosis refers to the presence in the blood of poikilocytes. Poikilocytes are abnormally shaped red blood cells as seen on a blood film. Rather than being seen as a sign of any one disease, poikilocytosis is a rather general condition. There may, however be a predominance of one particular type of abnormally shaped red cells, some of which may indicate possible presence of a specific disease or disorder. [2]