Polycythemia vera laboratory tests

Laboratory findings associated with the diagnosis of polycythemia vera include erythrocytosis, leukocytosis, and thrombocytosis. The most sensitive test for polycythemia vera is JAK2 V617F mutation testing in the peripheral blood. A specific finding in patients with polycythemia vera is low erythropoietin level.

Laboratory findings associated with polycythemia vera include:^{[1][2][3][4][5][6]}

• Complete blood count

• Erythrocytosis
• Increased hemoglobin
• Thrombocytosis
• Leukocytosis
• Increased basophils and eosinophils

• The following blood levels may be elevated in blood chemistry (non specific):

• Blood urea nitrogen (BUN)
• Creatinine
• Phosphate
• Lactate dehydrogenase (LDH)
• Alanine aminotransferase (ALT)
• Aspartate transaminase (AST)
• Uric acid

• Peripheral blood mutational testing

• JAK2 V617F mutation or JAK2 exon 12 mutation

• Bleeding and clotting factor

• Elevation of prothrombin time (PT) or international normalized ratio (INR)
• Elevation of partial thromboplastin time (PTT)

• Erythropoietin (EPO)

• It is usually low in polycythemia vera but can be normal in about 20% of patients.
• It is usually high in secondary polycythemia vera.

• Bone marrow biopsy

• Elevation of white blood cells, red blood cells, and platelets

Template:Hematology

Template:WikiDoc Sources