Portal vein thrombosis epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

The incidence of portal vein thrombosis in cirrhosis patients is unknown. The prevalence of portal vein thrombosis is approximately 5000-10,000 per 100,000 in overall cases of portal hypertension in developed counties and 40,000 per 100,000 in developing countries. The overall mortality rate of portal vein thrombosis is less than 10% except for patients with malignancy or cirrhosis. Patients of all age groups may develop portal vein thrombosis. There is no racial predilection to portal vein thrombosis. Portal vein thrombosis affects men and women equally.

Epidemiology and Demographics

Incidence

The incidence of portal vein thrombosis in cirrhosis patients is unknown.^[1]

Prevalence

The prevalence of portal vein thrombosis is approximately 5000-10,000 per 100,000 in overall cases of portal hypertension in developed counties and 40,000 per 100,000 in developing countries.^[1]^[2]
The prevalence of portal vein thrombosis is less than 1000 per 100,000 in patients with compensated cirrhosis, but is 8000-25000 per 100,000 in patients who are candidates for liver transplantation.^[3]^[4]^[5]

Mortality rate

The overall mortality rate of portal vein thrombosis is less than 10% except for patients with malignancy or cirrhosis.^[1]
The mortality rate of portal vein thrombosis in patients with malignancy or cirrhosis about 26%.^[6]
In patients with chronic portal vein thrombosis one-year survival alters from 80% to 95%, and 3-year survival varies from 75% to 90%.^[7]

Age

Patients of all age groups may develop portal vein thrombosis.^[1]
The incidence of portal vein thrombosis increases with age and it commonly affects individuals 66-70 years in men and 69-74 years in women.^[2]

Race

There is no racial predilection to portal vein thrombosis.

Gender

Portal vein thrombosis affects men and women equally.^[2]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A (2010). “Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment”. World J. Gastroenterol. 16 (2): 143–55. PMC 2806552. PMID 20066733.
↑ ^2.0 ^2.1 ^2.2 Ogren M, Bergqvist D, Björck M, Acosta S, Eriksson H, Sternby NH (2006). “Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies”. World J. Gastroenterol. 12 (13): 2115–9. PMC 4087695. PMID 16610067.
↑ Okuda K, Ohnishi K, Kimura K, Matsutani S, Sumida M, Goto N, Musha H, Takashi M, Suzuki N, Shinagawa T (1985). “Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients”. Gastroenterology. 89 (2): 279–86. PMID 4007419.
↑ Francoz C, Belghiti J, Vilgrain V, Sommacale D, Paradis V, Condat B, Denninger MH, Sauvanet A, Valla D, Durand F (2005). “Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation”. Gut. 54 (5): 691–7. doi:10.1136/gut.2004.042796. PMC 1774501. PMID 15831918.
↑ Fimognari FL, Violi F (2008). “Portal vein thrombosis in liver cirrhosis”. Intern Emerg Med. 3 (3): 213–8. doi:10.1007/s11739-008-0128-0. PMID 18274708.
↑ Chawla YK, Bodh V (2015). “Portal vein thrombosis”. J Clin Exp Hepatol. 5 (1): 22–40. doi:10.1016/j.jceh.2014.12.008. PMC 4415192. PMID 25941431.
↑ Parikh, Sameer; Shah, Riddhi; Kapoor, Prashant (2010). “Portal Vein Thrombosis”. The American Journal of Medicine. 123 (2): 111–119. doi:10.1016/j.amjmed.2009.05.023. ISSN 0002-9343.

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[pmid20066733-1] 1.0 ^1.1 ^1.2 ^1.3 Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A (2010). “Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment”. World J. Gastroenterol. 16 (2): 143–55. PMC 2806552. PMID 20066733.

[pmid16610067-2] 2.0 ^2.1 ^2.2 Ogren M, Bergqvist D, Björck M, Acosta S, Eriksson H, Sternby NH (2006). “Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies”. World J. Gastroenterol. 12 (13): 2115–9. PMC 4087695. PMID 16610067.

[pmid4007419-3] Okuda K, Ohnishi K, Kimura K, Matsutani S, Sumida M, Goto N, Musha H, Takashi M, Suzuki N, Shinagawa T (1985). “Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients”. Gastroenterology. 89 (2): 279–86. PMID 4007419.

[pmid15831918-4] Francoz C, Belghiti J, Vilgrain V, Sommacale D, Paradis V, Condat B, Denninger MH, Sauvanet A, Valla D, Durand F (2005). “Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation”. Gut. 54 (5): 691–7. doi:10.1136/gut.2004.042796. PMC 1774501. PMID 15831918.

[pmid18274708-5] Fimognari FL, Violi F (2008). “Portal vein thrombosis in liver cirrhosis”. Intern Emerg Med. 3 (3): 213–8. doi:10.1007/s11739-008-0128-0. PMID 18274708.

[pmid25941431-6] Chawla YK, Bodh V (2015). “Portal vein thrombosis”. J Clin Exp Hepatol. 5 (1): 22–40. doi:10.1016/j.jceh.2014.12.008. PMC 4415192. PMID 25941431.

[ParikhShah2010-7] Parikh, Sameer; Shah, Riddhi; Kapoor, Prashant (2010). “Portal Vein Thrombosis”. The American Journal of Medicine. 123 (2): 111–119. doi:10.1016/j.amjmed.2009.05.023. ISSN 0002-9343.

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