Klebs and colleagues showed that the clinical findings were consistent with a form of glomerulonephritis that was associated with the period following scarlet fever. In 1812, Wells showed that a latent period was required for edema and red urine seem to be present. In 1905 and 1933, Reichel and Osman further elaborated on PSGN and revealed detailed findings and description of the disease, its prevalence, its clinical findings, and its outcome, respectively. In 1903 when Clemens von Pirquet hypothesized the presence of immune complexes that might be the culprit of PSGN. In 1941, Seegal and Earle determined the nephritogenic properties of streptococcal strains and differentiated streptococcal strains based on their nephritogenic vs. rheumatic complication.

• In 1812, Wells showed that a latent period was required for edema and red urine seem to be present.^[1]
• Klebs and colleagues showed that the clinical findings were consistent with a form of glomerulonephritis that was associated with the period following scarlet fever.
• In 1905 and 1933, Reichel and Osman further elaborated on PSGN and revealed detailed findings and description of the disease, its prevalence, its clinical findings, and its outcome, respectively.
• In 1903 when Clemens von Pirquet hypothesized the presence of immune complexes that might be the culprit of PSGN, based on his clinical observations during his pediatric residency training. His theory was outlined and sent to the Academy of Sciences in Vienna and was read in the Academy in 1908.^[2]
• In 1941, Seegal and Earle determined the nephritogenic properties of streptococcal strains and differentiated streptococcal strains based on their nephritogenic vs. rheumatic complication.