Post-thrombotic syndrome future or investigational therapies

The field of PTS still holds many unanswered questions that are important targets for more research. Those include

• fully defining the pathophysiology of PTS, including the role of inflammation and residual thrombus after completion of an appropriate duration of anticoagulant therapy
• developing a PTS risk prediction model
• role of thrombolysis (“clot-busting” drugs) in PTS prevention
• defining the true efficacy of elastic compression stockings for PTS prevention (and if effective, elucidating the minimum compression strength necessary and the optimal timing and duration of compression therapy)
• whether PTS prevention methods are necessary for patients with asymptomatic or distal DVT
• additional treatment options for PTS with demonstrated safety and efficacy (compression and pharmacologic therapies)