Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Prenylamine
Introduction
Overview
Overview
Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false positives for it in drug tests.[1][2][3] Prenylamine also appears to act as a vesicular monoamine transporter inhibitor, and has been demonstrated to deplete vesicular monoamine neurotransmitter stores similarly to reserpine.[4]
References
References
- ↑ Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). “Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS”. Journal of Analytical Toxicology. 27 (2): 68–73. doi:10.1093/jat/27.2.68. PMID 12669999.
- ↑ Musshoff F (February 2000). “Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine”. Drug Metabolism Reviews. 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.
- ↑ Cody JT (May 2002). “Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results”. Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine. 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689.
- ↑ Bagchi SP (1990). “Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine”. Life Sciences. 46 (12): 857–63. doi:10.1016/0024-3205(90)90115-8. PMID 1969603.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]