Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Primary biliary cirrhosis classification

Introduction

Overview

Overview

There is no established system for the classification of primary biliary cirrhosis. However, it can be classified into four stages according to histological classification of Ludwig. It can also be classified into four stages according to the histological classification of P. Scheuer.

Classification

Classification

  • There is no established system for the classification of primary biliary cirrhosis.
  • However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.[1][2]
  • It can also be classified into four stages according to the histological classification of P. Scheuer.[3]
Classification of Primary biliary cirrhosis on the basis of histology
Stage Histologic appearance
Ludwig classification Scheuer’s classification
Stage 1 Portal inflammation Florid duct lesion or chronic non-suppurative destructive cholangitis
Stage 2 Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss Proliferation of the small bile ductules
Stage 3 Presence of fibrous septa linking adjacent portal tracts Fibrosis or scarring
Stage 4 Cirrhosis Cirrhosis
References

References

  1. ↑ Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ; et al. (2009). “Primary biliary cirrhosis”. Hepatology. 50 (1): 291–308. doi:10.1002/hep.22906. PMID 19554543.
  2. ↑ Ludwig J, Dickson ER, McDonald GS (1978). “Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)”. Virchows Arch A Pathol Anat Histol. 379 (2): 103–12. PMID 150690.
  3. ↑ Scheuer P (1967). “Primary biliary cirrhosis”. Proc R Soc Med. 60 (12): 1257–60. PMC 1901478. PMID 6066569.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2] Anmol Pitliya, M.B.B.S. M.D.[3]