Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Primary biliary cirrhosis laboratory findings
Introduction
Overview
Overview
Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include elevated levels of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, anti-mitochondrial antibodies, lipids, immunoglobulin M, liver aminotransferases.
Laboratory Findings
Laboratory Findings
- Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:[1][2][3][4]
- Hyperbilirubinemia
- Elevated alkaline phosphatase (2–10 times upper limit of normal)
- Elevated gamma-glutamyl transpeptidase (GGT)
- Elevated serum anti-mitochondrial antibodies (AMA) in more than 90% patients (titres of 1/40 or greater)
- Hyperlipidemia
- Elevated immunoglobulin M
- Elevated liver aminotransferase
- Some patients with primary biliary cirrhosis may have “nuclear-rim” and “multiple nuclear-dot” patterns, which is highly specific for primary biliary cirrhosis, particularly in AMA-negative patients.
- Some patients with primary biliary cirrhosis may have elevated antinuclear antibody (35% patients) and anti-smooth muscle antibody (66% patients).
References
References
- ↑ Kumagi T, Heathcote EJ (2008). “Primary biliary cirrhosis”. Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.
- ↑ Talwalkar JA, Lindor KD (2003). “Primary biliary cirrhosis”. Lancet. 362 (9377): 53–61. doi:10.1016/S0140-6736(03)13808-1. PMID 12853201.
- ↑ Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ; et al. (1986). “Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?”. Hepatology. 6 (6): 1279–84. PMID 3793004.
- ↑ Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA; et al. (1992). “Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?”. Hepatology. 15 (5): 858–62. PMID 1568727.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]