Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Primary central nervous system lymphoma other diagnostic studies
Introduction
Overview
Overview
Other diagnostic studies for primary central nervous system lymphoma include magnetic resonance spectroscopy, magnetic resonance perfusion, scintigraphy, stereotactic biopsy, and polymerase chain reaction.[1][2][3][4]
Other Diagnostics Studies
Other Diagnostics Studies
Magnetic Resonance Spectroscopy
- Magnetic resonance spectroscopy may be diagnostic of primary central nervous system lymphoma. Findings on MR spectroscopy suggestive of primary central nervous system lymphoma include:[1]
- Large choline peak
- Reversed choline/creatinine ratio
- Markedly decreased N-Acetylaspartate (NAA)
- Lactate peak may also be observed
Magnetic Resonance Perfusion
- Magnetic resonance perfusion may be diagnostic of primary central nervous system lymphoma. Findings on MR perfusion suggestive of primary central nervous system lymphoma include a modest increase in relative cerebral blood flow (rCBV), much less marked than in high-grade gliomas, where angiogenesis is a prominent feature.[1]
Scintigraphy
- Findings on scintigraphy suggestive of primary central nervous system lymphoma include:[1]
- Thallium 201: increased uptake
- C11 Methionine PET: increased uptake
Biopsy
- Stereotactic biopsy is usually performed to confirm a diagnosis of primary central nervous system lymphoma, especially in people who do not have AIDS.[2]
Bone Marrow Biopsy
- Bone marrow biopsy may be performed to detect metastases of primary central nervous system lymphoma to the bones.[3]
Polymerase Chain Reaction
Polymerase chain reaction (PCR) of the cerebrospinal fluid (CSF) may be performed to look for positive Epstein-Barr virus DNA in patients with primary central nervous system lymphoma, to establish the association with the virus.[4]
References
References
- ↑ 1.0 1.1 1.2 1.3 Radiographic features of primary CNS lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016
- ↑ 2.0 2.1 Diagnosis of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 18, 2016
- ↑ 3.0 3.1 Diagnostics of primary CNS lymphoma. National cancer institute 2016. http://www.cancer.gov/types/lymphoma/hp/primary-cns-lymphoma-treatment-pdq. Accessed on February 19, 2016
- ↑ 4.0 4.1 Haldorsen, Ingfrid S; KrÃ¥kenes, Jostein; Goplen, Anne K; Dunlop, Oona; Mella, Olav; Espeland, Ansgar (2008). “AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989–2003”. BMC Cancer. 8 (1): 225. doi:10.1186/1471-2407-8-225. ISSN 1471-2407.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]