Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Primary central nervous system lymphoma other imaging findings
Introduction
Overview
Overview
Besides MRI, thallium single-photon emission computed tomography (SPECT) scans have been studied as a diagnostic tool to distinguish between PCNSL and cerebral toxoplasmosis. It was expected that lymphoma cells with a high metabolism would accumulate more thallium than infected,inflamed or normal tissue. Initial thallium SPECT studies showed very high sensitivity and specificity of increased thallium uptake for PCNSL versus cerebral toxoplasmosis in HIV patients. Diagnostic accuracy of 201thallium SPECT is affected by the size, location, malignancy grade, and presence of necrotic and hemorrhagic areas in the lesion.
Other Imaging Findings
Other Imaging Findings
- Besides MRI, thallium single-photon emission computed tomography (SPECT) scans have been studied as a diagnostic tool to distinguish between PCNSL and cerebral toxoplasmosis.
- It was expected that lymphoma cells with a high metabolism would accumulate more thallium than infected,inflamed or normal tissue.
- Initial thallium SPECT studies showed very high sensitivity and specificity of increased thallium uptake for PCNSL versus cerebral toxoplasmosis in HIV patients.
- subsequent studies showed a lower diagnostic accuracy, with a reported mean sensitivity and specificity of 92% and 89% respectively.
- Diagnostic accuracy of 201thallium SPECT is affected by the size, location, malignancy grade, and presence of necrotic and hemorrhagic areas in the lesion.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]