Primary central nervous system lymphoma other imaging findings

Besides MRI, thallium single-photon emission computed tomography (SPECT) scans have been studied as a diagnostic tool to distinguish between PCNSL and cerebral toxoplasmosis. It was expected that lymphoma cells with a high metabolism would accumulate more thallium than infected,inflamed or normal tissue. Initial thallium SPECT studies showed very high sensitivity and specificity of increased thallium uptake for PCNSL versus cerebral toxoplasmosis in HIV patients. Diagnostic accuracy of 201thallium SPECT is affected by the size, location, malignancy grade, and presence of necrotic and hemorrhagic areas in the lesion.

• Besides MRI, thallium single-photon emission computed tomography (SPECT) scans have been studied as a diagnostic tool to distinguish between PCNSL and cerebral toxoplasmosis.
• It was expected that lymphoma cells with a high metabolism would accumulate more thallium than infected,inflamed or normal tissue.
• Initial thallium SPECT studies showed very high sensitivity and specificity of increased thallium uptake for PCNSL versus cerebral toxoplasmosis in HIV patients.
• subsequent studies showed a lower diagnostic accuracy, with a reported mean sensitivity and specificity of 92% and 89% respectively.
• Diagnostic accuracy of 201thallium SPECT is affected by the size, location, malignancy grade, and presence of necrotic and hemorrhagic areas in the lesion.

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