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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Primary central nervous system lymphoma surgery

Introduction

Overview

Overview

Surgical intervention is not recommended for the management of primary central nervous system lymphoma, because the tumors are often deeply seated and spread throughout the brain.

Surgery

Surgery

  • Surgery does not play a role in the treatment of primary central nervous system lymphoma because the tumors are often spread throughout the brain and located deep within the brain.[1]
  • A surgery for stereotactic biopsy may be done to make a diagnosis.[1]
  • Surgical resection is usually ineffective because of the depth of the tumor.
  • Treatment with irradiation and corticosteroids often only produces a partial response, but tumor recurs in more than 90% of patients.
  • Median survival is 10 to 18 months in immunocompetent patients, and less in those with AIDS.
  • The addition of IV methotrexate and citrovorum may extend survival to a median of 3.5 years. If radiation is added to methotrexate, median survival may increase beyond 4 years.
  • Radiation is not recommended in conjunction with methotrexate because of increased risk of leukoencephalopathy and dementia in patients older than 60 years of age[2]
References

References

  1. ↑ 1.0 1.1 Treatment of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 18, 2016
  2. ↑ Deangelis LM, Hormigo A. Treatment of primary central nervous system lymphoma. Semin Oncol 2004; 31:684-692. In AIDS patients, perhaps the most important factor with respect to treatment is the use of highly active anti-retroviral therapy (HAART), which affects the CD4+ lymphocyte population and the level of immunosuppression


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]