Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Primary cutaneous follicle centre lymphoma natural history, complications and prognosis
Introduction
Overview
Overview
Prognosis is generally excellent, and the 5-year survival rate of patients with primary cutaneous follicle centre lymphoma is approximately 97%.
Natural History
Natural History
- Primary cutaneous follicle centre lymphoma shows a predilection for the scalp, forehead, and trunk and dissemination to extracutaneous sites rarely occurs.[1]
- Cutaneous relapses noted in ~30% of patients.[2]
- Recurrences usually proximate to the initial site of the tumor.
- Untreated skin lesions increase in size, rarely metastases to other sites.
Complications
Complications
- Transformation of systemic follicular lymphoma (FL) into aggressive non-Hodgkin’s lymphoma is associated with poor prognosis and has been reported with a wide range of frequency (range between 10%–70%).
- While the annual risk of transformation of systemic follicular lymphoma (FL) is 3%.
Prognosis
Prognosis
- Prognosis is generally excellent, and the 5-year survival rate of patients with primary cutaneous follicle centre lymphoma is approximately 97%.
- The International Extranodal Lymphoma Study Group identified three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status.[3]
- Elevated LDH
- More than two skin lesions
- Nodular lesions
- If left untreated, the lesions typically increase in size over years.
- In approximately 10 percent of patients may disseminate to extracutaneous sites.
References
References
- ↑ Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/. Accessed on March 02, 2016
- ↑ Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
- ↑ Wilcox RA (2015). “Cutaneous B-cell lymphomas: 2015 update on diagnosis, risk-stratification, and management”. Am. J. Hematol. 90 (1): 73–6. doi:10.1002/ajh.23863. PMID 25535037.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]