Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Primary hyperaldosteronism causes
Introduction
Overview
Overview
Common causes of primary hyperaldosteronism are aldosterone-secreting adenoma, bilateral hyperplasia of the adrenal glands, and ectopic secretion of aldosterone from ovaries and kidneys. Less common causes of primary hyperaldosteronism are familial hyperaldosteronism types I-III, pure aldosterone-producing adrenocortical carcinomas, and unilateral hyperplasia of the adrenal gland.
Causes
Causes
Common Causes
Common causes of primary hyperaldosteronism (PA) may be divided into:[1][2]
- Adrenal causes:
- Aldosterone-secreting adrenal adenoma (APA-benign tumor, 50-60%)
- Idiopathic hyperaldosteronism (IHA-Bilateral hyperplasia of the adrenal gland, 40-50%)
- Extra-adrenal causes
- Ectopic secretion of aldosterone (ovaries and kidneys)
Less Common Causes
Less common causes of primary hyperladosteronism include:[3][4][5]
- Familial hyperaldosteronism type I (glucocorticoid-remediable aldosteronism [GRA])
- Familial hyperaldosteronism type II (the familial occurrence of APA or bilateral idiopathic hyperplasia or both)
- Familial hyperaldosteronism type III (associated with the germline mutation in the KCNJ5 potassium channel)
- Pure aldosterone-producing adrenocortical carcinomas
- Unilateral adrenal hyperplasia
References
References
- ↑ “Primary aldosteronism: renaissance of a syndrome – Young – 2007 – Clinical Endocrinology – Wiley Online Library”.
- ↑ Aronova A, Iii TJ, Zarnegar R (2014). “Management of hypertension in primary aldosteronism”. World J Cardiol. 6 (5): 227–33. doi:10.4330/wjc.v6.i5.227. PMC 4062125. PMID 24944753.
- ↑ “Primary aldosteronism: renaissance of a syndrome – Young – 2007 – Clinical Endocrinology – Wiley Online Library”.
- ↑ So A, Duffy DL, Gordon RD, Jeske YW, Lin-Su K, New MI, Stowasser M (2005). “Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity”. J. Hypertens. 23 (8): 1477–84. PMID 16003173.
- ↑ Song MS, Seo SW, Bae SB, Kim YJ, Kim SJ (2012). “Aldosterone-producing adrenocortical carcinoma without hypertension”. Korean J. Intern. Med. 27 (2): 221–3. doi:10.3904/kjim.2012.27.2.221. PMC 3372808. PMID 22707896.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]