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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Primary sclerosing cholangitis classification

Introduction

Overview

Overview

Primary sclerosing cholangitis may be classified according to the size of bile ducts involved, as well as its association with autoimmune hepatitis. The three main subtypes are the classic subtype, small ducts subtype, and primary sclerosing cholangitis associated with autoimmune hepatitis.

Classification

Classification

Primary sclerosing cholangitis may be divided into 3 subtypes, according to the type of ducts involved, as well as its association with autoimmune hepatitis:[1][2][3][4]

Subtype Ducts Involved Diagnostic Procedure Histopathology
Classic Small and large bile ducts MRCP, ERCP Mixed inflammatory cells around bile ducts; nonspecific and nondiagnostic finding
Small duct Small bile ducts only Liver biopsy Mixed inflammatory cells around bile ducts; nonspecific and nondiagnostic finding
Associated with autoimmune hepatitis Small and large bile ducts MRCP, ERCP Lymphoplasmacytic infiltrate, associated with interface hepatitis
References

References

  1. ↑ Lazaridis KN, LaRusso NF (2016). “Primary Sclerosing Cholangitis”. N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
  2. ↑ Angulo P, Maor-Kendler Y, Lindor KD (2002). “Small-duct primary sclerosing cholangitis: a long-term follow-up study”. Hepatology. 35 (6): 1494–500. doi:10.1053/jhep.2002.33202. PMID 12029635.
  3. ↑ Feldstein AE, Perrault J, El-Youssif M, Lindor KD, Freese DK, Angulo P (2003). “Primary sclerosing cholangitis in children: a long-term follow-up study”. Hepatology. 38 (1): 210–7. doi:10.1053/jhep.2003.50289. PMID 12830004.
  4. ↑ Kaya M, Angulo P, Lindor KD (2000). “Overlap of autoimmune hepatitis and primary sclerosing cholangitis: an evaluation of a modified scoring system”. J. Hepatol. 33 (4): 537–42. PMID 11059857.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]