Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Prokaryotic release factors

Introduction

There are three known prokaryotic release factors involved in the termination of translation.

  • RF1 recognizes the stop codon UAG
  • RF2 recognizes the stop codon UGA (both RF1 and RF2 recognize the stop codon UAA)
  • RF3 promotes termination by either factor by accelerating dissociation.

The release factors provide the means of termination by having a conformation that mimics that of tRNA molecules. The decoding release factor binds to the A site of the ribosome and directly recognise the stop codon [1]. Once RF1 (or RF2) and RF3 are bound to the ribosome, the polypeptide is released, and the ribosome and release factors dissasemble, thus completing the process of translation [2].

References

  1. ↑ “Direct recognition of mRNA stop signals by Escherichia coli polypeptide chain release factor two”. Retrieved 2006-11-28.
  2. ↑ “Mapping Functionally Important Motifs SPF and GGQ of the Decoding Release Factor RF2 to the Escherichia coli Ribosome by Hydroxyl Radical Footprinting”. Retrieved 2006-11-28.