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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Prokineticin

Introduction

Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]

Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[4]

Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[5]

See also

See also

References

References

  1. ↑ “RCSB Protein Data Bank – Structure Summary for 2KRA – Solution structure of Bv8”.
  2. ↑ Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY (2001). “Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle”. Mol. Pharmacol. 59 (4): 692–8. PMID 11259612.
  3. ↑ 3.0 3.1 Morales RA, Daly NL, Vetter I, et al. (September 2010). “Chemical synthesis and structure of the prokineticin Bv8”. Chembiochem. 11 (13): 1882–8. doi:10.1002/cbic.201000330. PMID 20677202.
  4. ↑ Negri L, Lattanzi R, Giannini E, Melchiorri P (September 2007). “Bv8/Prokineticin proteins and their receptors”. Life Sci. 81 (14): 1103–16. doi:10.1016/j.lfs.2007.08.011. PMID 17881008.
  5. ↑ Narula, Harmeet S.; Carlson, Harold E. (2014). “Gynaecomastia—pathophysiology, diagnosis and treatment”. Nature Reviews Endocrinology. 10 (11): 684–698. doi:10.1038/nrendo.2014.139. ISSN 1759-5029. PMID 25112235.
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