Prolactinoma epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2], Faizan Sheraz, M.D. [3]

Overview

About 45% of pituitary adenomas are prolactinomas, making it the most common type of all pituitary adenomas. Worldwide, the prevalence of sporadic prolactinoma is 6 to 10 per 100,000 persons. The prevalence of prolactinoma in people less than 20 years old is 10 per 100,000 individuals worldwide. Prolactinoma most commonly affects women in reproductive age group (20 to 50 years). Prolactinoma is more common in females than males in people between 20 and 50 years old. Distribution among males and females becomes similar after age 50.

Epidemiology and Demographics

Prevalence

45% of pituitary adenomas are prolactinomas, making it the most common type of all pituitary adenomas.^[1]
Worldwide, the prevalence of sporadic prolactinoma ranges from a low of 6 persons per 100,000 persons to a high of 10 persons per 100,000 persons.
Worldwide, the prevalence of prolactinoma in people less than 20 years old is 10 individuals per 100,000 individuals.
Clinically significant pituitary tumors affect the health of approximately 14 people per 100,000 people in United States.
Some growth hormone-producing tumors also co-secrete prolactin.
Microprolactinoma are much more common than macroprolactinoma.

Incidence

Worldwide, the incidence of sporadic prolactinoma is 1 person per 100,000 persons per year.^[1]

Age

Age specific distribution of prolactinoma is as follows:^[1]^[2]
- Prolactinoma commonly affects individuals between 20 and 50 years old.
- Prolactinoma occur less commonly in people less than 20 years old, with a prevalence of 10 per 100,000 individuals. These tumors account for less than 2% of intracranial tumors in this age group.

Gender

Women usually have microprolactinoma whereas men usually have macroadenoma.^[1]
Gender-based frequency of prolactinoma depends on the age of the individual:
- Age group: 20 to 50 years
  - Women are more commonly affected by prolactinoma than men. The female to male ratio is approximately 10:1.^[1]
  - Women aged 20 to 30 years have the highest prevalance of prolactinoma, with a female to male ratio of approximately 14:1.
- Age group: >50 years^[2]
  - Men and women are affected equally after age 50 years.
  - The prevalence of prolactinoma increases with age in men after age 50 and peaks during ages 60 to 70 years. At this time, the female to male ratio is 1:3.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ciccarelli A, Daly AF, Beckers A (2005). “The epidemiology of prolactinomas”. Pituitary. 8 (1): 3–6. doi:10.1007/s11102-005-5079-0. PMID 16411062.
↑ ^2.0 ^2.1 Mindermann T, Wilson CB (1994). “Age-related and gender-related occurrence of pituitary adenomas”. Clin Endocrinol (Oxf). 41 (3): 359–64. PMID 7893282.

Template:WikiDoc Sources

[pmid16411062-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ciccarelli A, Daly AF, Beckers A (2005). “The epidemiology of prolactinomas”. Pituitary. 8 (1): 3–6. doi:10.1007/s11102-005-5079-0. PMID 16411062.

[pmid7893282-2] 2.0 ^2.1 Mindermann T, Wilson CB (1994). “Age-related and gender-related occurrence of pituitary adenomas”. Clin Endocrinol (Oxf). 41 (3): 359–64. PMID 7893282.

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