Common symptoms of prolactinoma include headache, vision changes, decreased libido, infertility, and osteoporosis. In women, common symptoms of prolactinoma include breast tenderness, galactorrhea, and amenorrhea or oligomenorrhea.

Obtaining the history is one of the most important aspects of making a diagnosis of prolactinoma. A complete history will help determine the correct therapy and helps in determining the prognosis.

• Specific areas of focus when obtaining the past medical history are outlined below:
  • Headache
  • Vision changes and visual field defects
  • Delayed puberty in adolescence
  • Decreased sexual drive (libido)
  • Infrequent menstrual period or absent menstrual period
  • Breast tenderness
  • Abnormal milk flow from the breast in a woman who is not pregnant or nursing

• Family history of multiple endocrine neoplasia type 1 (MEN1) is assosciated with a higher chance of developing pitutary adenomas (prolactinomas being the most common type of pitutary adenomas).

Symptoms of prolactinoma can be divided as follows:^[1]

• Symptoms due to hyperprolactinemia
• Symptoms due to mass effect

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