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Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Protein SET
Introduction
Protein SET is a protein that in humans is encoded by the SET gene.[1][2][3]
References
References
- β von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). “Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene”. Molecular and Cellular Biology. 12 (8): 3346β55. doi:10.1128/mcb.12.8.3346. PMCΒ 364582. PMIDΒ 1630450.
- β Li M, Makkinje A, Damuni Z (May 1996). “The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A”. The Journal of Biological Chemistry. 271 (19): 11059β62. doi:10.1074/jbc.271.19.11059. PMIDΒ 8626647.
- β “Entrez Gene: SET SET translocation (myeloid leukemia-associated)”.
- β 4.0 4.1 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). “Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein”. Cell. 104 (1): 119β30. doi:10.1016/s0092-8674(01)00196-9. PMIDΒ 11163245.
- β Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). “HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A”. Molecular and Cellular Biology. 22 (8): 2810β20. doi:10.1128/mcb.22.8.2810-2820.2002. PMCΒ 133744. PMIDΒ 11909973.
- β Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). “The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity”. The Journal of Biological Chemistry. 277 (9): 7324β32. doi:10.1074/jbc.M107270200. PMIDΒ 11741927.
- β Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). “Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain”. Molecular and Cellular Biology. 23 (23): 8528β41. doi:10.1128/mcb.23.23.8528-8541.2003. PMCΒ 262669. PMIDΒ 14612398.
- β Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). “Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor”. Cell. 112 (5): 659β72. doi:10.1016/s0092-8674(03)00150-8. PMIDΒ 12628186.
Further reading
Further reading
- Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). “Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis”. Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4279β83. doi:10.1073/pnas.92.10.4279. PMCΒ 41927. PMIDΒ 7753797.
- Maruyama K, Sugano S (Jan 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1β2): 171β4. doi:10.1016/0378-1119(94)90802-8. PMIDΒ 8125298.
- Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). “Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia”. FEBS Letters. 340 (3): 231β5. doi:10.1016/0014-5793(94)80144-4. PMIDΒ 8131851.
- Vaesen M, Barnikol-Watanabe S, GΓΆtz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). “Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII”. Biological Chemistry Hoppe-Seyler. 375 (2): 113β26. doi:10.1515/bchm3.1994.375.2.113. PMIDΒ 8192856.
- Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). “Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia”. The Journal of Biological Chemistry. 269 (3): 2258β62. PMIDΒ 8294483.
- Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). “HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A”. The Journal of Biological Chemistry. 272 (45): 28407β14. doi:10.1074/jbc.272.45.28407. PMIDΒ 9353299.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1β2): 149β56. doi:10.1016/S0378-1119(97)00411-3. PMIDΒ 9373149.
- Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). “Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms’ tumor”. Journal of the American Society of Nephrology. 9 (10): 1873β80. PMIDΒ 9773788.
- Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). “Protein ligands to HuR modulate its interaction with target mRNAs in vivo”. The Journal of Cell Biology. 151 (1): 1β14. doi:10.1083/jcb.151.1.1. PMCΒ 2189805. PMIDΒ 11018049.
- Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). “Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators”. Molecular and Cellular Biology. 20 (23): 8933β43. doi:10.1128/MCB.20.23.8933-8943.2000. PMCΒ 86548. PMIDΒ 11073993.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). “DNA cloning using in vitro site-specific recombination”. Genome Research. 10 (11): 1788β95. doi:10.1101/gr.143000. PMCΒ 310948. PMIDΒ 11076863.
- Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). “Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein”. Cell. 104 (1): 119β30. doi:10.1016/S0092-8674(01)00196-9. PMIDΒ 11163245.
- Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). “Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET”. European Journal of Biochemistry / FEBS. 268 (5): 1340β51. doi:10.1046/j.1432-1327.2001.02000.x. PMIDΒ 11231286.
- Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). “Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks”. The Journal of Biological Chemistry. 276 (46): 43285β93. doi:10.1074/jbc.M108137200. PMIDΒ 11555662.
- Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). “The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity”. The Journal of Biological Chemistry. 277 (9): 7324β32. doi:10.1074/jbc.M107270200. PMIDΒ 11741927.
- Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). “HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A”. Molecular and Cellular Biology. 22 (8): 2810β20. doi:10.1128/MCB.22.8.2810-2820.2002. PMCΒ 133744. PMIDΒ 11909973.
- Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). “The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing”. The Journal of Biological Chemistry. 277 (28): 25026β31. doi:10.1074/jbc.M202256200. PMIDΒ 11978794.
