Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Pseudoxanthoma elasticum natural history, complications and prognosis
Introduction
Overview
Overview
The ocular involvement including retinal hemorrhages can progressively lead to loss of central vision, sparing the peripheral vision. The involvement of the elastic media and intima of the arteries can lead to claudication, hypertension, angina pectoris, myocardial infarction, and gastrointestinal or cerebral hemorrhage which could be fatal, although relatively uncommon. The prognosis of PXE largely depends on the extracutaneous organ manifestations. The occurence of myocardial infarction, cerebral or GI hemorrhage may have fatal consequences. Spontaneous resolution of skin changes has been reported, but is exceedingly rare.[1]
References
References
- ↑ Chassaing, N.; Martin, L.; Calvas, P.; Le Bert, M.; Hovnanian, A. (2005). “Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations”. J Med Genet. 42 (12): 881–92. doi:10.1136/jmg.2004.030171. PMID 15894595. Unknown parameter
|month=ignored (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayokunle Olubaniyi, M.B,B.S [2]