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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Psoriatic arthritis natural history, complications and prognosis

Introduction

Overview

Overview

If left untreated psoriatic arthritis may lead to severe joint destruction and deformity resulting in loss of physical function and reduced quality of life. Psoriatic arthritis is associated with various comorbid conditions including cardiovascular disease ( increased risk of atherosclerosis, myocardial infarction, heart failure), metabolic syndrome, liver disease, diabetes mellitus, depression and osteoporosis. Prognosis is good with early diagnosis and treatment. Overall survival rate also depends on management of comorbid conditions along with arthritis treatment.

Natural History, Complications and Prognosis

Natural History, Complications and Prognosis

References

References

  1. ↑ Han C, Robinson DW, Hackett MV, Paramore LC, Fraeman KH, Bala MV (November 2006). “Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis”. J. Rheumatol. 33 (11): 2167–72. PMIDΒ 16981296.
  2. ↑ Labitigan M, Bahče-Altuntas A, Kremer JM, Reed G, Greenberg JD, Jordan N, Putterman C, Broder A (April 2014). “Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis”. Arthritis Care Res (Hoboken). 66 (4): 600–7. doi:10.1002/acr.22185. PMCΒ 3969762. PMIDΒ 24115739.
  3. ↑ Eder L, Wu Y, Chandran V, Cook R, Gladman DD (September 2016). “Incidence and predictors for cardiovascular events in patients with psoriatic arthritis”. Ann. Rheum. Dis. 75 (9): 1680–6. doi:10.1136/annrheumdis-2015-207980. PMIDΒ 26493817.
  4. ↑ Rohekar S, Tom BD, Hassa A, Schentag CT, Farewell VT, Gladman DD (January 2008). “Prevalence of malignancy in psoriatic arthritis”. Arthritis Rheum. 58 (1): 82–7. doi:10.1002/art.23185. PMIDΒ 18163513.
  5. ↑ McDonough E, Ayearst R, Eder L, Chandran V, Rosen CF, Thavaneswaran A, Gladman DD (May 2014). “Depression and anxiety in psoriatic disease: prevalence and associated factors”. J. Rheumatol. 41 (5): 887–96. doi:10.3899/jrheum.130797. PMIDΒ 24692521.
  6. ↑ Ciacli C, Cojocaru M (2012). “Systemic osteoporosis–major complication of psoriatic arthritis”. Rom J Intern Med. 50 (2): 173–8. PMIDΒ 23326962.
  7. ↑ Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg JD, Kavanaugh A, Reed G, Strand V, Kremer JM (January 2010). “Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide”. Ann. Rheum. Dis. 69 (1): 43–7. doi:10.1136/ard.2008.101378. PMCΒ 2794929. PMIDΒ 19147616.
  8. ↑ McLaughlin M, OstΓΆr A (December 2014). “Early treatment of psoriatic arthritis improves prognosis”. Practitioner. 258 (1777): 21–4, 3. PMIDΒ 25603589.
  9. ↑ Buckley C, Cavill C, Taylor G, Kay H, Waldron N, Korendowych E, McHugh N (October 2010). “Mortality in psoriatic arthritis – a single-center study from the UK”. J. Rheumatol. 37 (10): 2141–4. doi:10.3899/jrheum.100034. PMIDΒ 20682670.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]