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Pyrilamine extended release

Introduction

Overview

Overview

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

Synthesis

Synthesis

Pyrilamine synthesis:[3][4][5]
See also

See also

References

References

  1. ↑ Parsons, Mike E.; Ganellin, C. Robin (January 2006). “Histamine and its receptors”. British Journal of Pharmacology. 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096.
  2. ↑ Active Ingredients for Midol Complete
  3. ↑ R.J. Horclois, Template:US Patent (1950).
  4. ↑ Template:Cite doi
  5. ↑ D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]