Pyrvinium
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Pyrvinium is an anthelmintic effective for pinworms.[1] Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate.[2][3]
Pyrvinium salts can also inhibit the growth of cancer cells.[4] More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation.[5]
Synthesis
Synthesis
One synthetic method is based on Skraup synthesis and Paal-Knorr synthesis.[4] More recently, an alternative convergent, synthetic strategy to pyrvinium triflate salts through Friedländer synthesis was reported.[3]
References
References
- ↑ PMID 14027194 (PMID 14027194)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PubChem: Pyrvinium
- ↑ 3.0 3.1 An, Jing; Mao, Yongjun; Lin, Nan; Tian, Wang; Huang, Ziwei (2012). “New Synthesis of Pyrvinium That inhibits the β-Catenin/Tcf4 Pathway”. Heterocycles. 85 (5): 1179–1185. doi:10.3987/COM-12-12446.
- ↑ 4.0 4.1 WO 2006078754, J. E. Macdonald, M. K. Hysell, D. Yu, H. Li, and F. Wong-Staal, “Novel Quinolinium Salts and Derivatives”, published 2006-07-27
- ↑ PMID 15298733 (PMID 15298733)
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