Health Dictionary
Reliable, easy-to-read patient information on common medical conditions â written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
RIPK4
Introduction
Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.[1][2]
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.[2]
References
References
- â Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). “The DNA sequence of human chromosome 21”. Nature. 405 (6784): 311â9. doi:10.1038/35012518. PMIDÂ 10830953.
- â 2.0 2.1 “Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4”.
- â Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). “Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase”. J. Biol. Chem. United States. 276 (24): 21737â44. doi:10.1074/jbc.M008069200. ISSNÂ 0021-9258. PMIDÂ 11278382.
Further reading
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791â806. doi:10.1101/gr.6.9.791. PMIDÂ 8889548.
- Bhr C, Rohwer A, Stempka L, et al. (2000). “DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis”. J. Biol. Chem. 275 (46): 36350â7. doi:10.1074/jbc.M004771200. PMIDÂ 10948194.
- Chen L, Haider K, Ponda M, et al. (2001). “Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase”. J. Biol. Chem. 276 (24): 21737â44. doi:10.1074/jbc.M008069200. PMIDÂ 11278382.
- Meylan E, Martinon F, Thome M, et al. (2003). “RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-ÎșB and is processed during apoptosis”. EMBO Rep. 3 (12): 1201â8. doi:10.1093/embo-reports/kvf236. PMCÂ 1308326. PMIDÂ 12446564.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899â903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMCÂ 139241. PMIDÂ 12477932.
- Moran ST, Haider K, Ow Y, et al. (2003). “Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner”. J. Biol. Chem. 278 (24): 21526â33. doi:10.1074/jbc.M301575200. PMIDÂ 12676934.
- Scanlan MJ, Gout I, Gordon CM, et al. (2003). “Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression”. Cancer Immun. 1: 4. PMIDÂ 12747765.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40â5. doi:10.1038/ng1285. PMIDÂ 14702039.
- Adams S, Pankow S, Werner S, Munz B (2007). “Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair”. J. Invest. Dermatol. 127 (3): 538â44. doi:10.1038/sj.jid.5700588. PMIDÂ 17039240.
External links
External links
- RIPK4 human gene location in the UCSC Genome Browser.
- RIPK4 human gene details in the UCSC Genome Browser.