Health Dictionary
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RIT1
Introduction
GTP-binding protein Rit1 is a protein that in humans is encoded by the RIT1 gene.[1][2][3]
Function
Function
RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM][3]
References
References
- β Lee CH, Della NG, Chew CE, Zack DJ (November 1996). “Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins”. The Journal of Neuroscience. 16 (21): 6784β94. PMIDΒ 8824319.
- β Wes PD, Yu M, Montell C (November 1996). “RIC, a calmodulin-binding Ras-like GTPase”. The EMBO Journal. 15 (21): 5839β48. PMCΒ 452332. PMIDΒ 8918462.
- β 3.0 3.1 “Entrez Gene: RIT1 Ras-like without CAAX 1”.
- β Gos M, Fahiminiya S, PoznaΕski J, Klapecki J, Obersztyn E, Piotrowicz M, Wierzba J, Posmyk R, Bal J, Majewski J (September 2014). “Contribution of RIT1 mutations to the pathogenesis of Noonan syndrome: four new cases and further evidence of heterogeneity”. American Journal of Medical Genetics. Part A. 164A (9): 2310β6. doi:10.1002/ajmg.a.36646. PMIDΒ 24939608.
- β Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). “BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase”. The Journal of Biological Chemistry. 283 (17): 11083β96. doi:10.1074/jbc.M708473200. PMCΒ 2431063. PMIDΒ 18303015.
- β Huang J, Chen J (July 2008). “VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation”. Oncogene. 27 (29): 4056β64. doi:10.1038/onc.2008.44. PMIDΒ 18332868.
Further reading
Further reading
- Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). “Biochemical characterization of the Ras-related GTPases Rit and Rin”. Archives of Biochemistry and Biophysics. 371 (2): 207β19. doi:10.1006/abbi.1999.1448. PMIDΒ 10545207.
- Shao H, Andres DA (September 2000). “A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras”. The Journal of Biological Chemistry. 275 (35): 26914β24. doi:10.1074/jbc.M002241200. PMIDΒ 10869344.
- Hynds DL, Spencer ML, Andres DA, Snow DM (May 2003). “Rit promotes MEK-independent neurite branching in human neuroblastoma cells”. Journal of Cell Science. 116 (Pt 10): 1925β35. doi:10.1242/jcs.00401. PMIDΒ 12668729.
- Li JT, Liu W, Kuang ZH, Zhang RH, Chen HK, Feng QS (February 2004). “[Mutation and amplification of RIT1 gene in hepatocellular carcinoma]”. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 21 (1): 43β6. PMIDΒ 14767908.
- Shi GX, Andres DA (January 2005). “Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades”. Molecular and Cellular Biology. 25 (2): 830β46. doi:10.1128/MCB.25.2.830-846.2005. PMCΒ 543422. PMIDΒ 15632082.
- Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). “High-throughput mapping of a dynamic signaling network in mammalian cells”. Science. 307 (5715): 1621β5. doi:10.1126/science.1105776. PMIDΒ 15761153.
- Benmaamar R, Pagano M (September 2005). “Involvement of the SCF complex in the control of Cdh1 degradation in S-phase”. Cell Cycle. 4 (9): 1230β2. doi:10.4161/cc.4.9.2048. PMIDΒ 16123585.