Health Dictionary
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RNF34
Introduction
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.[1][2]
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]
References
References
- ↑ Sasaki S, Nakamura T, Arakawa H, Mori M, Watanabe T, Nagawa H, Croce CM (Jul 2002). “Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer”. Oncogene. 21 (32): 5024–30. doi:10.1038/sj.onc.1205627. PMID 12118383.
- ↑ 2.0 2.1 “Entrez Gene: RNF34 ring finger protein 34”.
Further reading
Further reading
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- McDonald ER, El-Deiry WS (2004). “Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth”. Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Sasaki S, Watanabe T, Konishi T, et al. (2005). “Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence”. J. Exp. Clin. Cancer Res. 23 (3): 507–12. PMID 15595643.
- Konishi T, Sasaki S, Watanabe T, et al. (2005). “Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells”. Mol. Cancer Ther. 4 (5): 743–50. doi:10.1158/1535-7163.MCT-05-0020. PMID 15897238.
- Rual JF, Venkatesan K, Hao T, et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.