Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
ROCK2
Introduction
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [1]
Function
Function
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
References
References
- ↑ “Entrez Gene: Rho associated coiled-coil containing protein kinase 2”. Retrieved 2016-04-21.
Further reading
Further reading
- Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). “Kinetic mechanism for human Rho-Kinase II (ROCK-II)”. Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.