Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Raine syndrome
Introduction
Raine syndrome (also called osteosclerotic bone dysplasia) is a rare disease in newborns characterized by craniofacial anomalies including microcephaly, exophthalmos, midface hypoplasia, cleft palate, gum hypertrophy and generalized osteosclerosis on radiography. It is usually lethal within a few hours after birth.
References
- Kan A, Kozlowski K (1992). “New distinct lethal osteosclerotic bone dysplasia (Raine syndrome)”. Am J Med Genet. 43 (5): 860–4. PMID 1642277.
- Rejjal A (1998). “Raine syndrome”. Am J Med Genet. 78 (4): 382–5. PMID 9714445.
- Rickert C, Rieder H, Rehder H, Hülskamp G, Hörnig-Franz I, Louwen F, Paulus W (2002). “Neuropathology of Raine syndrome”. Acta Neuropathol (Berl). 103 (3): 281–7. PMID 11907809.
- Al-Gazali L, Jehier K, Nazih B, Abtin F, Haas D, Sadagahatian R (2003). “Further delineation of Raine syndrome”. Clin Dysmorphol. 12 (2): 89–93. PMID 12868469.