Rapidly progressive glomerulonephritis causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]
Overview
Overview
Rapidly progressive glomerulonephritis can be caused by multiple factors.These include life threatening conditions such as sepsis and other pre existing renal diseases.Infections, drugs and some types of cancer also cause RPGN.
Causes
Causes
Life-threatening Causes
Common Causes
Common causes of rapidly progressive glomerulonephritis may include[1][2][3]
- Goodpasture syndrome[4]
- Post streptococcal glomerulonephritis[5]
- Lupus nephritis
- Henoch-Schönlein purpural)
- Immunoglobulin A nephropathy
- Mixed cryoglobulinemia
- Membranoproliferative glomerulonephritis
- Granulomatosis with polyangiitis (Wegener granulomatosis)>[6].
- Microscopic polyangiitis (MPA)[7]
- Renal-limited necrotizing crescentic glomerulonephritis (NCGN)
- Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome
Less Common Causes
Less common causes of rapidly progressive glomerulonephritis include:
- Cryoglobulinemia
- Systemic necrotizng vasculitis
- Colon cancer
- Lung cancer
- Lymphoma
- Allopurinol
- Hydralazine
- Rifampin
- Behcet’s disease
- Renal-limited necrotizing crescentic glomerulonephritis (NCGN)
Genetic Causes
- Rapidly progressive glomerulonephritis is more common in people who have HLA DP1, DQ and DRB4s.
Causes by Organ System
| Cardiovascular | Infective endocarditis |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Hydralazine,Allopurinol,Rifampin |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | Colon cancer |
| Genetic | HLA DP1, HLA DQ, HLA DRB4s |
| Hematologic | Lymphoma, Henoch-Schönlein purpural) |
| Iatrogenic | No underlying causes |
| Infectious Disease | Hepatitis B,Hepatitis C |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Colon cancer, Pulmonary cancer, Lymphoma |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Lung cancer |
| Renal/Electrolyte | Postinfectious glomerulonephritis,Lupus nephritis,Immunoglobulin A nephropathy ,Membranoproliferative glomerulonephritis, Renal-limited necrotizing crescentic glomerulonephritis (NCGN) |
| Rheumatology/Immunology/Allergy | Goodpasture syndrome, SLE, Behcet’s disease, Granulomatosis with polyangiitis (Wegener granulomatosis), Microscopic polyangiitis, Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome), |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Sepsis |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Allopurinol
- Behcet’s disease
- Colon cancer
- Cryoglobulinemia
- Diabetic nephropathy
- Eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome)
- Goodpasture syndrome
- Granulomatosis with polyangiitis (Wegener granulomatosis)
- Henoch-Schönlein purpura
- Hydralazine
- Immunoglobulin A nephropathy
- Infective endocarditis
- Lung cancer
- Lupus nephritis
- Lymphoma
- Membranoproliferative glomerulonephritis
- Microscopic polyangiitis (MPA)
- Renal-limited necrotizing crescentic glomerulonephritis (NCGN)
- Rifampin
- Sepsis
- Systemic necrotizng vasculitis
References
References
- ↑ Huang XR, Tipping PG, Apostolopoulos J, Oettinger C, D’Souza M, Milton G; et al. (1997). “Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats”. Clin Exp Immunol. 109 (1): 134–42. PMC 1904710. PMID 9218836.
- ↑ Syed R, Rehman A, Valecha G, El-Sayegh S (2015). “Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis”. Biomed Res Int. 2015: 402826. doi:10.1155/2015/402826. PMC 4673333. PMID 26688808.
- ↑ Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). “Histopathologic classification of ANCA-associated glomerulonephritis”. J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
- ↑ Couser WG (1988). “Rapidly progressive glomerulonephritis: classification, pathogenetic mechanisms, and therapy”. Am J Kidney Dis. 11 (6): 449–64. PMID 3287904.
- ↑ Roy S, Murphy WM, Arant BS (1981). “Poststreptococcal crescenteric glomerulonephritis in children: comparison of quintuple therapy versus supportive care”. J Pediatr. 98 (3): 403–10. PMID 7205449.
- ↑ Yang G, Tang Z, Chen Y, Zeng C, Chen H, Liu Z; et al. (2005). “Antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with anti-GBM crescentic glomerulonephritis”. Clin Nephrol. 63 (6): 423–8. PMID 15960143.
- ↑ Heeringa P, Brouwer E, Klok PA, Huitema MG, van den Born J, Weening JJ; et al. (1996). “Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat”. Am J Pathol. 149 (5): 1695–706. PMC 1865281. PMID 8909258.
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