
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions โ written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Rapidly progressive glomerulonephritis future or investigational therapies
Introduction
Stem Cell Therapy:
Stem cell therapy is at an early phase of development, but it can be a good future therapeutic strategy in immune-mediated renal disease. There is some experimental evidence in animal models of anti-GBM disease, where mesenchymal stem cells were usedwheres, which are progenitors of renal tissue. ]. A case of NCGN due to MPA successfully treated with stem cell therapy has been reported. The patient’s serum creatinine peaked at 690 ยตmol/L; standard therapy with cyclophosphamide and glucocorticoids was ineffective, and rituximab was not tolerated; following treatment with autologous mesenchymal stem cells, the patient’s creatinine came down to 168 ยตmol/L in parallel with a reduction in the ANCA titre.[1]
References
- โ Huang ZY, Hong LQ, Na N, Luo Y, Miao B, Chen J (March 2012). “Infusion of mesenchymal stem cells overexpressing GDNF ameliorates renal function in nephrotoxic serum nephritis”. Cell Biochem. Funct. 30 (2): 139โ44. doi:10.1002/cbf.1827. PMIDย 22105543.
