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Rapidly progressive glomerulonephritis future or investigational therapies

Introduction

Stem Cell Therapy:

Stem cell therapy is at an early phase of development, but it can be a good future therapeutic strategy in immune-mediated renal disease. There is some experimental evidence in animal models of anti-GBM disease, where mesenchymal stem cells were usedwheres, which are progenitors of renal tissue. ]. A case of NCGN due to MPA successfully treated with stem cell therapy has been reported. The patient’s serum creatinine peaked at 690 ยตmol/L; standard therapy with cyclophosphamide and glucocorticoids was ineffective, and rituximab was not tolerated; following treatment with autologous mesenchymal stem cells, the patient’s creatinine came down to 168 ยตmol/L in parallel with a reduction in the ANCA titre.[1]

References

  1. โ†‘ Huang ZY, Hong LQ, Na N, Luo Y, Miao B, Chen J (March 2012). “Infusion of mesenchymal stem cells overexpressing GDNF ameliorates renal function in nephrotoxic serum nephritis”. Cell Biochem. Funct. 30 (2): 139โ€“44. doi:10.1002/cbf.1827. PMIDย 22105543.