Relaxin receptor
The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
| RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
| RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
| RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
See also
See also
References
References
- ↑ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). “International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides”. Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
- ↑ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). “Relaxin family peptide receptors–former orphans reunite with their parent ligands to activate multiple signalling pathways”. Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.
External links
External links
- “Relaxin Family Peptide Receptors: Motilin”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- relaxin+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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