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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Relaxin receptor

Introduction

The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]

Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.

receptor/gene ligands activates inhibits
RXFP1 relaxin 1, relaxin 2, relaxin 3 adenylate cyclase, protein kinase A, protein kinase C,

phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)

RXFP2 relaxin 1, relaxin 2, insulin-like 3 adenylate cyclase
RXFP3 relaxin 3 Erk1/2 signaling adenylate cyclase
RXFP4 relaxin 3, insulin-like 3 adenylate cyclase
See also

See also

References

References

  1. ↑ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). “International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides”. Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
  2. ↑ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). “Relaxin family peptide receptors–former orphans reunite with their parent ligands to activate multiple signalling pathways”. Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.
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