Renal agenesis history and symptoms

Since patients with unilateral renal agenesis (URA) have an increased risk for proteinuria, hypertension, and renal insufficiency, checking for symptoms of these complications should be considered. Checking for other contralateral congenital anomaly of kidney or urinary tract (CAKUT) such as VUR (vesicoureteral reflux) and PUJO (pelviureteric junction obstruction), extra-renal anomalies in different organs (such as cardiac, lung, gastrointestinal, genital, skeleton, and vertebral) , and associated syndromes and sequences (such as VACTERL, CHARGE and Trisomy 18) should be considered when URA is diagnosed.

Maternal history during pregnancy for the following may be important in unilateral renal disease (URA):^[1]

• Uncontrolled diabetes
• Treatment for hypertension

The following may be important to check in the family history of patients with URA:^[2] 

• URA
• CAKUT (congenital anomalies of the kidney and urinary tract)
• End stage renal disease (ESRD)
• Consanguinity

Since patients with unilateral renal agenesis (URA) have an increased risk for proteinuria, hypertension, and renal insufficiency, checking for symptoms of these complications should be considered.^[2]

Checking for other contralateral congenital anomaly of kidney or urinary tract (CAKUT) such as VUR (vesicoureteral reflux) and PUJO (pelviureteric junction obstruction), extra-renal anomalies in different organs (such as cardiac, lung, gastrointestinal, genital, skeleton, and vertebral) , and associated syndromes and sequences (such as VACTERL, CHARGE and Trisomy 18) should be considered when URA is diagnosed.^[3][4]

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