Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Renal agenesis pathophysiology
Introduction
Overview
Overview
Renal agenesis results from the failure of the ureteric bud to form the ureter, renal pelvis and the collecting duct system and the failure of the renal mesenchyme to form nephrons.
Pathophysiology
Pathophysiology
- Renal development (interactions between the ureteric bud (mesonephric duct) and the metanephric mesenchyme) starts at the 5th week of gestation.[1]
- Renal agenesis results from:[2]
- Failure of the ureteric bud to form the ureter, renal pelvis and the collecting duct system
- Failure of the renal mesenchyme to form nephrons
- Renal agenesis is a congenital condition caused by the complete failure of embryonic kidney formation.[3]
- Unilateral renal agenesis (URA) is the one-sided congenital failure of embryonic kidney formation.[4][5]
- In URA, the contralateral solitary kidney usually functions normally and may become hyperthrophied.[6]
References
References
- ↑ Schedl A (2007). “Renal abnormalities and their developmental origin”. Nat Rev Genet. 8 (10): 791–802. doi:10.1038/nrg2205. PMID 17878895.
- ↑ Kerecuk L, Schreuder MF, Woolf AS (2008). “Renal tract malformations: perspectives for nephrologists”. Nat Clin Pract Nephrol. 4 (6): 312–25. doi:10.1038/ncpneph0807. PMID 18446149.
- ↑ Laurichesse Delmas H, Kohler M, Doray B, Lémery D, Francannet C, Quistrebert J; et al. (2017). “Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries”. Birth Defects Res. 109 (15): 1204–1211. doi:10.1002/bdr2.1065. PMID 28722320.
- ↑ Robson WL, Leung AK, Rogers RC (1995). “Unilateral renal agenesis”. Adv Pediatr. 42: 575–92. PMID 8540439.
- ↑ Woolf AS, Hillman KA (2007). “Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives”. BJU Int. 99 (1): 17–21. doi:10.1111/j.1464-410X.2006.06504.x. PMID 16956352.
- ↑ Cho JY, Moon MH, Lee YH, Kim KW, Kim SH (2009). “Measurement of compensatory hyperplasia of the contralateral kidney: usefulness for differential diagnosis of fetal unilateral empty renal fossa”. Ultrasound Obstet Gynecol. 34 (5): 515–20. doi:10.1002/uog.7336. PMID 19852048.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]