Renal amyloidosis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

Renal amyloidosis can be classified according to the site of amyloid deposition into glomerular, vascular, and tubular amyloidosis.

Classification

Renal amyloidosis may be classified according to site of amyloid deposition into 3 subtypes:^[1]

Renal amyloidosis may be classified according to type of amyloidogenic protein into 3 subtypes:^[2]

	Amyloidosis type	Amyloidogenic protein
Common types	AL/AHL/AH (Primary amyloidosis)	Ig light chains (AL)
		Fragments of Ig heavy chains and light chains (AHL)
		Fragments of heavy chains only (AH)
	AA (Secondary amyloidosis)	Serum amyloid A
Rare types	AFib	Fibrinogen A α chain
	AApo AI/AII/AIV	Apo AI, Apo AII, or Apo AIV
	ATTR	Transthyretin
	ALys	Lysozyme
	AGel	Gelsolin
	ALECT2	Leukocyte chemotactic factor 2

References

↑ Bilginer Y, Akpolat T, Ozen S (August 2011). “Renal amyloidosis in children”. Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.
↑ Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH (September 2013). “Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases”. Clin J Am Soc Nephrol. 8 (9): 1515–23. doi:10.2215/CJN.10491012. PMC 3805078. PMID 23704299.

Overview