Renal amyloidosis natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

If left untreated, renal amyoidosis may progress into end stage renal disease. Common complications include chronic renal failure and nephrotic syndrome. After a few years, renal amyloidosis eventually leads to end stage renal disease and it may be accelerated by some factors such as steroid administration, renal vein thrombos, iInfections and surgery.

Natural History, Complications, and Prognosis

Natural History

If renal amyloidosis left untreated it usually manifests as nephrotic range proteinuria and then progresses to acute kidney injury and then end stage renal disease.^[1]

Complications

Common complications of renal amyloidosis include:^[2]^[3]

ESRD
Systemic organ involvement

Prognosis

After a few years, renal amyloidosis eventually leads to end stage renal disease. Disease progression is worsened in presence of certain factors such as:^[4]

Steroid administration
Renal vein thrombosis
Infections
Surgery

References

↑ Lohani S, Schuiteman E, Garg L, Yadav D, Zarouk S (2016). “Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis”. Case Rep Nephrol. 2016: 8690642. doi:10.1155/2016/8690642. PMC 5093243. PMID 27840752.
↑ Bilginer Y, Akpolat T, Ozen S (August 2011). “Renal amyloidosis in children”. Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.
↑ Hajra A, Bandyopadhyay D (2016). “An interesting case of renal amyloidosis”. Indian J Nephrol. 26 (6): 467–469. doi:10.4103/0971-4065.177143. PMC 5131391. PMID 27942184.
↑ Kaaroud H, Ben Moussa F, Goucha R, Abderrahim E, Ben Hamida F, Ben Hamida F, Ben Hamida F, Kheder A, Ben Miaz H (May 1999). “Influence of surgery on renal amyloidosis”. Kidney Int. 55 (5): 2117–2133. doi:10.1046/j.1523-1755.1999.00455.x. PMID 10231478.

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[pmid27840752-1] Lohani S, Schuiteman E, Garg L, Yadav D, Zarouk S (2016). “Apolipoprotein C-II Deposition Amyloidosis: A Potential Misdiagnosis as Light Chain Amyloidosis”. Case Rep Nephrol. 2016: 8690642. doi:10.1155/2016/8690642. PMC 5093243. PMID 27840752.

[pmid21360109-2] Bilginer Y, Akpolat T, Ozen S (August 2011). “Renal amyloidosis in children”. Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.

[pmid27942184-3] Hajra A, Bandyopadhyay D (2016). “An interesting case of renal amyloidosis”. Indian J Nephrol. 26 (6): 467–469. doi:10.4103/0971-4065.177143. PMC 5131391. PMID 27942184.

[pmid10231478-4] Kaaroud H, Ben Moussa F, Goucha R, Abderrahim E, Ben Hamida F, Ben Hamida F, Ben Hamida F, Kheder A, Ben Miaz H (May 1999). “Influence of surgery on renal amyloidosis”. Kidney Int. 55 (5): 2117–2133. doi:10.1046/j.1523-1755.1999.00455.x. PMID 10231478.

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